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美国
| EPA/OCSPP Series 870, OECD Series 400, DOT 49 CFR | |||
| Acute Oral Toxic Class Determination | OCSPP 870.1000 | ||
| Acute Oral Toxicity – Up and Down Procedure (UPD) | OCSPP 870.1100, OECD 420 | ||
| Acute Dermal Toxicity/LD50 in Rabbits | OCSPP 870.1200, OECD 402 | ||
| Acute Inhalation Toxicity/LC50 in Rats | OCSPP 870.1300, OECD 403 | ||
| Acute Eye Irritation in Rabbits | OCSPP 870.2400 | ||
| Acute Dermal Irritation in Rabbits | OCSPP 870.2500, OECD 404 | ||
| Delayed Contact Dermal Sensitization Test (Buehler) | OCSPP 870.2600 | ||
| Guinea Pig Maximization Test (Magnusson-Kligman) | OECD 406 | ||
| FHSA | |||
| Single Dose Oral Toxicity/LD50 in Rats | |||
| Acute Dermal Toxicity in Rabbits | |||
| Primary Dermal Irritation/Corrosion in Rabbits | |||
| Acute Eye Irritation in Rabbits | |||
| Acute Inhalation Toxicity/LC50 in Rats | |||
| ISO/USP and SPECIALTY | |||
| Dermal Irritation | |||
| Muscle Implantation | |||
| Intracutaneous Irritation | |||
| Systemic Injection Test in Mice | |||
| ISO Guinea Pig Maximization Test (Magnusson-Kligman) | |||
| ISO Guinea Pig Sensitization Test (Buehler Method) | |||
| Comedogenicity Assay | |||
| Vaginal, Anal, Penile or Buccal Mucosal Irritation | |||
| In Vivo Photo-Irritation/Toxicity (in rodents) | |||
| Pharmacokinetic/Toxicokinetic Studies | |||
| Emesis Model | |||
| Intranasal Studies | |||
| Mouse Ear Swelling Test (MEST) | |||
| Wound-Healing Studies | |||
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| 3T3 Neutral Red Uptake Phototoxicity Test | OECD 432 | ||
| Agar Overlay or MEM Elution Cytotoxicity Assay | |||
| Cytotoxicity via Cell Proliferation or Neutral Red Uptake | |||
| MatTek Tissue Equivalent Assays: | |||
| EpiOcular™ MTT Viability, EpiOcular™ Eye Irritation Test (EIT) | OECD 492 | ||
| EpiDerm™ MTT Viability, EpiDerm™ Skin Irritation Test (SIT) | OECD 439 | ||
| EpiDerm™ Skin Corrosivity Test (SCT) | OECD 431 | ||
| EpiOral™ MTT Viability Assay | |||
| EpiVaginal™, EpiAirway™, EpiIntestinal™ | |||
| EpiDerm™ Phototoxicity Assay | |||
| In Vitro Testing with Cytokine Endpoints | |||
| Corrositex® | OECD 435 | ||
| Hens Eggs Test ChorioAllantoic Membrane Test (HET-CAM) | Invittox Protocol #47 | ||
| Bovine Corneal Opacity & Permeability (BCOP) Assay | OECD 437 | ||
| Chorioallantoic Membrane Vascular Assay (CAMVA) | |||
| Porcine Corneal Opacity Reversibility Assay (PorCORA) | |||
| IN VITRO AND ALTERNATIVE SENSITIZATION ASSAYS | |||
| Local Lymph Node Assay (LLNA) Flow Cytometry Method | OECD 429 | ||
| Local Lymph Node Assay (LLNA) BrdU-ELISA | OECD 442B | ||
| Photo-Local Lymph Node Assay (Photo-LLNA) – Photo-Sensitization Test | |||
| Photo-Mouse Ear Swelling Test (Photo-MEST) | |||
| Human Cell Line Activation Test (h-CLAT) | OECD 442E | ||
| In Vitro Sensitization (IVSA) in EpiDerm™ | |||
| Direct Peptide Reactivity Assay - Subcontracted to EAG Laboratories | OECD 442C | ||
| GARDskin, GARDpotensy, GARDair | |||
| KeratinoSens/LuSens Assay - Subcontracted to Cyprotex Discovery | OECD 442D | ||
| GENOTOXICITY, FLOW CYTOMETRY, MECHANISTIC AND SPECIALTY ASSAYS | |||
| Bacterial Reverse Mutation Test (Ames) | OECD 471 / OCSPP 870.5100 | ||
| Anti-Angiogenesis Assay | |||
| Peroxide Production Assay (Lipid Peroxidation) | |||
| Nitric Oxide Synthase Activity (Irritation / Inflammatory Mediator) | |||
| Tyrosinase Activity/Inhibition Assays | |||