美国
|
Endpoint |
Class |
Study |
Guideline |
Test System |
|
Cytotoxicity |
In Vitro |
Agar Overlay Cytotoxicity Test |
ISO 10993-5 |
Cells |
|
Cytotoxicity |
In Vitro |
MEM Elution |
ISO 10993-5 |
Cells |
|
Cytotoxicity |
In Vitro |
Cytotoxicity via Cell Proliferation |
Nonguideline |
Cells |
|
Dermal Irritation |
In Vivo |
Primary Dermal Irritation/Corrosion in Rabbits |
16 CFR 1500.41 |
Rabbit |
|
Dermal Irritation |
In Vivo |
Skin Irritation Test in Albino Rabbits |
ISO 10993-10 |
Rabbit |
|
Dermal Irritation |
In Vitro |
MatTek EpiDerm™ MTT Viability Assay |
Nonguideline |
Tissue Model |
|
Dermal Irritation |
In Vitro |
MatTek EpiDerm™ Skin Irritation Test (SIT) |
OECD 440 |
Tissue Model |
|
Dermal Irritation |
In Vitro |
MatTek EpiDerm™ Corrosivity Assay (SCT) |
OECD 431 |
Tissue Model |
|
Dermal Irritation |
In Chemico |
Corrositex® |
OECD 435 |
Chemical Matrix |
|
Genotoxicity |
In Vitro |
Ames Assay |
OCSPP 870.5100 & OECD 471 |
Bacteria |
|
Local Tolerance |
In Vivo |
Muscle Implantation |
ISO-10993-6 |
None |
|
Local Tolerance |
In Vivo |
Subcutaneous Implantation |
ISO-10993-6 |
Rat |
|
Local Tolerance |
In Vivo |
Intracutaneous Irritation |
ISO 10993-10 |
Rabbit |
|
Local Tolerance |
In Vivo |
Intracutaneous (Intradermal) Reactivity Test in Rabbits |
ISO 10993-10 |
Rabbit |
|
Local Tolerance |
In Vivo |
Vaginal Irritation in Rabbits |
ISO 10993-10 |
Rabbit |
|
Local Tolerance |
In Vivo |
Vaginal and Anal Mucosal Irritation |
ISO 10993-10 |
Rabbit |
|
Local Tolerance |
In Vivo |
Penile Mucosal Irritation |
ISO 10993-10
|
Rabbit |
|
Local Tolerance |
In Vivo |
Hamster Cheek Pouch – Buccal Mucosal Irritation Study |
ISO 10993-10 |
Hamster |
|
Local Tolerance |
In Vitro |
MatTek EpiOral™ Assay |
Nonguideline |
Tissue Model |
|
Local Tolerance |
In Vitro |
MatTek EpiVaginal™ Assay |
Nonguideline |
Tissue Model |
|
Local Tolerance |
In Vitro |
MatTek EpiAirway™ Assay |
Nonguideline |
Tissue Model |
|
Ocular Irritation |
In Vivo |
Acute Eye Irritation/Corrosion in Rabbits |
OCSPP 870.2400 & OECD 405 |
Rabbit |
|
Ocular Irritation |
Ex Vivo |
Chorioallantoic Membrane Vascular Assay (CAMVA) |
Nonguideline |
Organotypic Model |
|
Ocular Irritation |
Ex Vivo |
Bovine Corneal Opacity & Permeability (BCOP) Assay |
Nonguideline |
Organotypic Model |
|
Ocular Irritation |
In Vitro |
BCOP/EIT Combination Assay |
OECD |
Organotypic Model |
|
Ocular Irritation |
Ex Vivo |
CAMVA + BCOP Combination Assay |
Nonguideline |
Organotypic Model |
|
Ocular Irritation |
Ex Vivo |
HET-CAM: INVITTOX Protocol No. 47 |
Nonguideline |
Organotypic Model |
|
Ocular Irritation |
Ex Vivo |
Porcine Corneal Opacity Reversibility Assay (PorCORA) |
Nonguideline |
Organotypic Model |
|
Ocular Irritation |
Ex Vivo |
Porcine Corneal Confocal Microscopy Cell Death Assay |
Nonguideline |
Organotypic Model |
|
Ocular Irritation |
In Vitro |
MatTek EpiOcular™ MTT Viability Assay |
Nonguideline |
Tissue Model |
|
Ocular Irritation |
In Vitro |
MatTek EpiOcular™ Eye Irritation test (EIT) |
OECD 492 |
Tissue Model |
|
Phototoxicity |
In Vivo |
Photo-Local Lymph Node Assay (Photo-LLNA) - Photo Allergy Test |
Nonguideline |
Mouse |
|
Phototoxicity |
In Vitro |
EpiDerm™ Phototoxicity Assay |
Nonguideline |
Tissue Model |
|
Phototoxicity |
In Vitro |
3T3 Neutral Red Uptake Phototoxicity Test |
OECD 432 |
Cells |
|
Phototoxicity |
In Vivo |
Dermal Phototoxicity in Mice (estimated price) |
Nonguideline |
Mouse |
|
Sensitization |
In Vivo |
Delayed Contact Dermal Sensitization Test - Buehler |
OCSPP 870.2600 & OECD 406 |
Guinea Pig |
|
Sensitization |
In Vivo |
Guinea Pig Maximization Test (Magnusson-Kligman) |
OCSPP 870.2600 & OECD 406 |
Guinea Pig |
|
Sensitization |
In Vivo |
Guinea Pig Maximization Test (Magnusson-Kligman) |
ISO 10993-10 |
Guinea Pig |
|
Sensitization |
In Vivo |
Guinea Pig Sensitization Test (Buehler Method) |
ISO 10993-10 |
Guinea Pig |
|
Sensitization |
In Vivo |
Local Lymph Node Assay (LLNA) (FCM) |
OCSPP 870.2600 & OECD 429 |
Mouse |
|
Sensitization |
In Vivo |
Local Lymph Node Assay (LLNA) (ELISA) |
OCSPP 870.2600 & OECD 442B |
Mouse |
|
Sensitization |
In Vivo |
Local Lymph Node Assay (LLNA) Single Dose (One Concentration) |
Nonguideline |
Mouse |
|
Sensitization |
In Vitro |
In Vitro Sensitization in MatTek EpiDerm™ (IVSA) |
Nonguideline |
Tissue Model |
|
Sensitization |
In Vitro |
Human Cell Line Activation Test (h-CLAT) |
OECD 442E |
Cells |
|
Sensitization |
In Chemico |
Direct Peptide Reactivity Assay (DPRA) |
OECD 442C |
Synthetic peptides |
|
Sensitization |
In Vitro |
KeratinoSens™ |
OECD 442D |
Cells |
|
Sensitization |
In Vitro |
LuSens |
OECD 442D |
Cells |
|
Sensitization |
In Vitro |
GARD™skin Dermal Sensitization |
Nonguideline |
Cells |
|
Sensitization |
In Vitro |
GARD™air Respiratory Sensitization |
Nonguideline |
Cells |
|
Special |
In Vivo |
Comedogenicity Assay |
Nonguideline |
Rabbit |
|
Special |
In Vitro |
Anti-Angiogenesis Assay |
Nonguideline |
Organotypic Model |
|
Special |
In Vitro |
Peroxide Production Assay (Lipid Peroxidation) |
Nonguideline |
Cells |
|
Special |
In Vitro |
Nitric Oxide Synthase Activity (Irritation / Inflammatory Mediator) |
Nonguideline |
Cells |
|
Special |
In Vitro |
Tyrosinase Inhibition Assay |
Nonguideline |
Cells |
|
Special |
In Vitro |
MatTek MelanoDerm™ Assay |
Nonguideline |
Tissue Model |
|
Systemic Toxicity |
In Vivo |
Acute Oral Toxicity – Up and Down Procedure (UPD) |
OECD 425 |
Rat |
|
Systemic Toxicity |
In Vivo |
Acute Oral Toxic Class Determination |
OCSPP 870.1000 & OECD 423 |
Rat |
|
Systemic Toxicity |
In Vivo |
Acute Dermal Toxicity/ LD50 in Rabbits |
OCSPP 870.1200 & OECD 402 |
Rabbit |
|
Systemic Toxicity |
In Vivo |
Acute Dermal Toxicity/ LD50 in Rats |
OCSPP 870.1200 & OECD 402 |
Rat |
|
Systemic Toxicity |
In Vivo |
Acute Dermal Irritation and Corrosion in Rabbits |
OCSPP 870.2500 & OECD 404 |
Rabbit |
|
Systemic Toxicity |
In Vivo |
Acute Inhalation Toxicity / LC50 in Rats |
OCSPP 870.1300 & OECD 403 |
Rat |
|
Systemic Toxicity |
In Vivo |
Acute Inhalation Toxicity of Aerosols in Rats |
OCSPP 870.1300 & OECD 403 |
Rat |
|
Systemic Toxicity |
In Vivo |
Single Dose Oral Toxicity in Rats |
Nonguideline |
Rat |
|
Systemic Toxicity |
In Vivo |
Acute Inhalation Toxicity / LC50 in Rats |
OCSPP 870.1300 & OECD 403 |
Rat |
|
Systemic Toxicity |
In Vivo |
Systemic Injection Test in Mice |
ISO-10993-11 |
Mouse |